Antioxidants increasingly have been praised for their benefits against disease and aging, but recent studies at Kansas State University show that they also can cause harm.

Researchers in K-State's Cardiorespiratory Exercise Laboratory have been studying how to improve oxygen delivery to the skeletal muscle during physical activity by using antioxidants, which are nutrients in foods that can prevent or slow the oxidative damage to the body. Their findings show that sometimes antioxidants can impair muscle function.

Antioxidant

"Antioxidant is one of those buzz words right now," said Steven Copp, a doctoral student in anatomy and physiology from Manhattan and a researcher in the lab. "Walking around grocery stores you see things advertised that are loaded with antioxidants.

I think what a lot of people don't realize is that the antioxidant and pro-oxidant balance is really delicate.

One of the things we've seen in our research is that you can't just give a larger dose of antioxidants and presume that there will be some sort of beneficial effect. In fact, you can actually make a problem worse."

David C. Poole and Timothy I. Musch, K-State professors from both the departments of kinesiology and anatomy and physiology, direct the Cardiorespiratory Exercise Laboratory, located in the College of Veterinary Medicine complex. Researchers in the lab study the physiology of physical activity in health and disease through animal models. Copp and Daniel Hirai, an anatomy and physiology doctoral student from Manhattan working in the lab, have conducted various studies associated with how muscles control blood flow and the effects of different doses and types of antioxidants.

Abnormalities in the circulatory system

Abnormalities in the circulatory system, such as those that result from aging or a disease like chronic heart failure, can impair oxygen delivery to the skeletal muscle and increase fatigability during physical activity, Copp said. The researchers are studying the effects antioxidants could have in the process.

"If you have a person trying to recover from a heart attack and you put them in cardiac rehab, when they walk on a treadmill they might say it's difficult," Poole said. "Their muscles get sore and stiff. We try to understand why the blood cells aren't flowing properly and why they can't get oxygen to the muscles, as happens in healthy individuals."

Some of the oxidants in our body, such as hydrogen peroxide, are helpful to increase blood flow.

Copp said there is a potential for antioxidants to reverse or partially reverse some of those changes that result from aging or disease. However, K-State's studies have shown that some of the oxidants in our body, such as hydrogen peroxide, are helpful to increase blood flow.

"We're now learning that if antioxidant therapy takes away hydrogen peroxide - or other naturally occurring vasodilators, which are compounds that help open blood vessels - you impair the body's ability to deliver oxygen to the muscle so that it doesn't work properly," Poole said.

Antioxidants can actually suppress key signaling mechanisms that are necessary for muscle to function effectively.

Poole said antioxidants are largely thought to produce better health, but their studies have shown that antioxidants can actually suppress key signaling mechanisms that are necessary for muscle to function effectively.

"It's really a cautionary note that before we start recommending people get more antioxidants, we need to understand more about how they function in physiological systems and circumstances like exercise," Poole said.

Mobility for advancing age and diseases like heart failure

Hirai said the researchers will continue to explore antioxidants and the effects of exercise training. Their studies are looking at how these can help individuals combat the decreased mobility and muscle function that comes with advancing age and diseases like heart failure.

"The research we do here is very mechanistic in nature, and down the road our aim is to take our findings and make recommendations for diseased and aging populations," Copp said.

The researchers have published their recent findings in several journals, including the Journal of Applied Physiology, Respiratory Physiology and Neurobiology, Microvascular Research, The American Journal of Physiology and Experimental Physiology.

The Cardiorespiratory Exercise Laboratory has been funded by grants from the National Institutes of Health, American Heart Association and intramural awards from the College of Veterinary Medicine.

Despite a general belief among physicians that extreme obesity is too difficult to treat, except with bariatric surgery, researchers at the Pennington Biomedical Research Center have learned a substantial proportion of individuals with extreme obesity can lose 10-percent or more of their body weight through medical treatment that does not include surgery.

10% Loss Improves Risk Factors and Health

Furthermore, even though those individuals are still obese, they have improvements in risk factors and other health markers.

Weight Loss Surgery Not Often Affordable or Reimbursed by Insurance

"This is important, because surgery is not often affordable or reimbursed by insurance," said leading scientist Dr. Donna Ryan. "In fact, many medical treatments are frequently not reimbursed by insurance if they are for obesity. So this research is needed to show that primary care doctors are capable of helping obese patients lose weight to improve health, even those with extreme obesity. "

Ryan said losing only five-percent of body weight can reap healthy benefits for the extremely obese, and nearly 61-percent of those in her clinical trial achieved that. More than 40-percent lost 10-percent body weight or more.

Physicians Trained in Intensive Medical Intervention

Ryan and her team spread out across Louisiana to recruit and train practicing physicians and their office staffs in eight cities in what she called "intensive medical intervention," in which physicians used a combination of medication, low-calorie diets and behavior changes. All of the techniques were endorsed by national guidelines for obesity management. Training of physicians and their staffs took about a day and a half.

Funded by the Louisiana Office of Group Benefits, which provides health coverage for state employees, the research team contacted state employees, seeking participants to screen for and enroll in the trial. Nearly 400 participants enrolled in the two-year trial, called LOSS, using the nearest trained physicians.

About half of the participants received the intensive medical intervention, the other half received what Ryan called "usual care." 

Program Starts with Low-calorie Liquid Diet

Those in the intense intervention group were immediately placed on a low-calorie liquid diet. They gradually moved to a low calorie, highly controlled diet using meal replacements, and received weight loss medication and group behavioral therapy that included lessons in exercise, activity, self-monitoring and recommendations for walking, water exercise and weight training. The group sessions were supervised by office staff.

Recommended Activities

• exercise
• activity
• self-monitoring
  
• recommendations for walking
• water exercise
  
• weight training

Success in Daily Routine of Doctor's Practice

"We conducted this trial as close to the reality of a typical clinic setting as we could," Ryan said, "We didn't want to learn just if these strategies worked, but if they would work in the daily routine of a doctor's practice."

Challenge of Keeping Weight Off

Ryan noted that the continual challenge in weight loss is keeping weight off, and that means sticking with a routine.

More than 50% of the LOSS participants stuck with it for two years or more, keeping much of the weight off, but Ryan said that does leave room for improving weight loss maintenance.

The LOSS trial results were published in the current issue of the Archives of Internal Medicine.

The Pennington Biomedical Research Center is a campus of the Louisiana State University System and conducts basic, clinical and population research.

More information about recalled food products is available on the Food Safety and Inspection Service Web site at http://www.fsis.usda.gov/

Federal Food Safety and Inspection
The Food Safety and Inspection Service (FSIS) is the public health agency in the U.S. Department of Agriculture responsible for ensuring that the nation's commercial supply of meat, poultry, and egg products is safe, wholesome, and correctly labeled and packaged.

Product Recall Specifics:  Call the Manufacturing  Company
Consumers with questions regarding recalled items should contact companies that issue recalls.

Testing Products for Safety
The Hygienic Laboratory in Iowa is one example of food testing to prevent outbreaks spreading. With techniques such as DNA fingerprinting, lab testing can identify specific contaminants, such as Salmonella.

The Hygienic Laboratory is the state of Iowa's environmental and public health laboratory, with facilities located at the University of Iowa's Research Campus in Iowa City and at the Iowa Lab Facilities in Ankeny, a Des Moines suburb. For more information about the laboratory and its programs and services, visit http://www.uhl.uiowa.edu.

Chronic kidney disease affects 26 million people in the United States.

Challenging prevailing wisdom that only children with end-stage kidney disease suffer physical, social, emotional and educational setbacks from their disease, research led by Johns Hopkins Children's Center shows that even mild to moderate kidney disease may seriously diminish a child's quality of life.

The findings, reported in the February issue of Pediatrics, suggest that earlier attention to quality-of-life issues in children with chronic kidney disease is needed.

"Even mild and moderate declines in kidney function may lead to serious physical, emotional, intellectual and social challenges," says lead investigator Arlene Gerson, Ph.D., a pediatric psychologist at Hopkins Children's.

Kidney Disease Screening is Needed

"What this means is we should be thinking about screening children for these challenges and intervening earlier than we once thought."

Recently diagnosed children who report learning problems may benefit from help before grades drop, researchers say, noting that children with chronic diseases currently do not qualify for special education until their scores decline dramatically.

Links Between Kidney Function and Quality of Life

In their study of 402 children, ages 2 to 16, with mild-to-moderate kidney disease, researchers analyzed the link between kidney function, disease severity, age of onset and disease duration, on the one hand, and physical, emotional, psychological and school functioning on the other.

The researchers also compared quality-of-life outcomes between healthy children and children with early-stage kidney disease. Children with mild-to-moderate kidney disease and their parents reported worse overall outcomes on standard quality-of-life questionnaires and worse outcomes on all quality-of-life factors.

Specifically, children with early-stage kidney disease scored on average 75 out of 100 on quality-of-life measures, compared to 83 out of 100 for healthy children. The difference was especially pronounced in school functioning, where children with early-stage kidney disease scored 64 out 100, compared to 80 out of 100 for healthy children.

How Children Cope with Kidney Disease

The study also found that the younger the child at the time of the diagnosis and the longer the child lived with kidney disease, the better the overall quality of life, a surprising finding, suggesting that as time passes children learn to cope better with their condition, the researchers say.

The researchers found that children with impaired growth and shorter stature, a common effect of their disease, had worse overall quality of life and poorer physical functioning, an indicator of the importance of early treatment.

Treatments for Children's Kidney Disease

"Timely and individually tailored treatment, be it with nutrition, salt supplements or growth hormones, if needed, can make a big difference. We cannot overemphasize the importance of early intervention in children with early stages of chronic kidney disease," says senior investigator Susan Furth, M.D. Ph.D., a pediatric nephrologist at Hopkins Children's.

The research is part of an ongoing 57-center study funded by the National Institutes of Health to study chronic kidney disease in children.

Reduce Heart Disease, Stroke and Heart Attacks

Scientists writing in The New England Journal of Medicine conclude that lowering the amount of salt people eat by even a small amount could reduce cases of heart disease, stroke and heart attacks as much as reductions in smoking, obesity and cholesterol levels.

If Americans consumed half a teaspoon less salt per day, there would be between 54,000 - 99,000 fewer heart attacks each year and between 44,000 - 92,000 fewer deaths, according to the study, which was conducted by scientists at University of California San Francisco, Stanford University Medical Center and Columbia University Medical Center.

Processed Foods are the Key Source of Salt

Health authorities at federal, state and municipal levels are considering policies to mandate that food companies reduce salt in processed foods, which are considered to be the source of much of the salt Americans eat.

For 40 years in this country we've been trying to get individuals to reduce the amount of sodium we consume and it hasn't worked.

New York City announced an initiative to urge food manufacturers and restaurant chains to reduce salt in their products nationwide by 25 percent over the next five years.

California, according to an author of the study, Kirsten Bibbins-Domingo, an associate professor of medicine and epidemiology at University of California, San Francisco, is considering setting salt limits on food the state purchase for schools, prisons and other public institutions.

The Institute of Medicine, the independent research arm of the National Academies of Science, will be issuing a report soon that will make recommendations about reducing salt intake, including actions government and manufacturers can take.

The Food and Drug Administration was considering whether to change the designation of salt from a food additive that is generally considered safe to a category that would require companies to give consumers more information alerting them to high levels of salt in food.

Greatest Benefit:  Blacks, Hypertension and Seniors

The researchers found that everyone would benefit from less salt, but people at higher risk for heart problems -- blacks, people with hypertension and people over 65 -- would benefit most.

While research isn't showing that individuals will be greatly affected by small changes in salt intake, "Small incremental changes in salt, such as lowering salt in tomato sauce or breads and cereals by a small amount, would achieve small changes in blood pressure that would have a measurable effect across the whole population," researchers said.

Huh?  Does YOUR salt intake affect MY health?   I understand public health concepts, but this seems a bit strained.  However, if what they mean is that people who eat way too much salt will take action and reduce their personal health... I can see that rationale. 

In the meantime, ask your medical adviser if you are overdoing the salt for your own good health!

Read More at NY Times

Researchers from the University of Alabama at Birmingham (UAB) have discovered that

restricting consumption of glucose, the most common dietary sugar, can extend the life of healthy human-lung cells and speed the death of precancerous human-lung cells, reducing cancer's spread and growth rate.

Calorie-Intake Restriction: Longevity and Prevent Diseases

The research has wide-ranging potential in age-related science, including ways in which calorie-intake restriction can benefit longevity and help prevent diseases like cancer that have been linked to aging, said principal investigator Trygve Tollefsbol, Ph.D., D.O., a professor in the Department of Biology.

• Extend the Lifespan of Healthy Cells
• Kill Off Cancer-Forming Cells
  

"These results further verify the potential health benefits of controlling calorie intake." Tollefsbol said. "Our research indicates that calorie reduction extends the lifespan of healthy human cells and aids the body's natural ability to kill off cancer-forming cells."

The UAB team conducted its tests by growing both healthy human-lung cells and precancerous human-lung cells in laboratory flasks. The flasks were provided either normal levels of glucose or significantly reduced amounts of the sugar compound, and the cells then were allowed to grow for a period of weeks.

"In that time, we were able to track the cells' ability to divide while also monitoring the number of surviving cells. The pattern that was revealed to us showed that restricted glucose levels led the healthy cells to grow longer than is typical and caused the precancerous cells to die off in large numbers," Tollefsbol said.

In particular, the researchers found that two key genes were affected in the cellular response to decreased glucose consumption. The first gene, telomerase, encodes an important enzyme that allows cells to divide indefinitely. The second gene, p16, encodes a well known anti-cancer protein.

Healthy Cell Growth

"Opposite effects were found for these genes in healthy cells versus precancerous cells. The healthy cells saw their telomerase rise and p16 decrease, which would explain the boost in healthy cell growth," Tollefsbol said. "The gene reactions flipped in the precancerous cells with telomerase decreasing and the anti-cancer protein p16 increasing, which would explain why these cancer-forming cells died off in large numbers."

The UAB research into the links between calorie intake, aging and the onset of diseases related to aging is thought to be a first of its kind given that it used the unique approach of testing human cells versus laboratory animals.

Caloric Restriction

"Our results not only support previous findings from the feeding of animals but also reveal that human longevity can be achieved at the cellular level through caloric restriction," Tollefsbol said.

"The hope is that this UAB breakthrough will lead to further discoveries in different cell types and facilitate the development of novel approaches to extend the lifespan of humans," he added.

Tollefsbol's research team included Yuanyuan Li, Ph.D., M.D., a UAB biology research associate, and Liang Liu, Ph.D., a UAB assistant professor of medicine.

The group's study titled "Glucose Restriction Can Extend Normal Cell Lifespan and Impair Precancerous Cell Growth Through Epigenetic Control of hTERT and p16 Expression" has been published in the online edition of The Journal of the Federation of American Societies for Experimental Biology, or FASEB Journal.

The research was funded by grants from the National Institutes of Health and the Glenn Foundation for Medical Research.

About UAB
Known for its innovative and interdisciplinary approach to education at both the graduate and undergraduate levels, UAB is an internationally renowned research university and academic medical center. Providing a broad-based graduate and undergraduate curriculum, the UAB Department of Biology is a dynamic academic partnership. Most members of the graduate faculty have research specialties in comparative biochemistry, physiology, environmental microbiology and eco-physiology of aquatic organisms.

Did You Know?

• About 76 million cases of food poisoning occur in the United States every year.
• Simply keeping cold foods cold and hot foods hot before serving can prevent many cases of food poisoning.
• Salmonella is better known, but another bacterium called Campylobacter (found on foods like raw chicken) is the No. 1 cause of food poisoning in the United States and the world.
• There are two main kinds of food poisoning. One results from toxins or poisons produced by microbes in food before consumption. The other results from microbes in food that infect the body and grow after consumption.
• Most cases of "24-hour flu," with its vomiting and diarrhea, actually are food poisoning.

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The Dietary Reference Intakes: The Essential Guide to Nutrient Requirements is sold only as a printed book; the PDF offered free of charge for download contains only the references.

Dietitians, community nutritionists, nutrition educators, nutritionists working in government agencies, and nutrition students at the postsecondary level, as well as other health professionals, will find Dietary Reference Intakes: The Essential Reference for Dietary Planning and Assessment an invaluable resource.

Widely regarded as the classic reference work for the nutrition, dietetic, and allied health professions since its introduction in 1943, Recommended Dietary Allowances has been the accepted source in nutrient allowances for healthy people. Responding to the expansion of scientific knowledge about the roles of nutrients in human health, the Food and Nutrition Board of the Institute of Medicine, in partnership with Health Canada, has updated what used to be known as Recommended Dietary Allowances (RDAs) and renamed their new approach to these guidelines Dietary Reference Intakes (DRIs). Since 1998, the Institute of Medicine has issued eight exhaustive volumes of DRIs that offer quantitative estimates of nutrient intakes to be used for planning and assessing diets applicable to healthy individuals in the United States and Canada. Now, for the first time, all eight volumes are summarized in one easy-to-use reference volume, Dietary Reference Intakes: The Essential Reference for Dietary Planning and Assessment. Organized by nutrient for ready use, this popular reference volume reviews the function of each nutrient in the human body, food sources, usual dietary intakes, and effects of deficiencies and excessive intakes. For each nutrient of food component, information includes:

Estimated average requirement and its standard deviation by age and gender.

Recommended dietary allowance, based on the estimated average requirement and deviation.

Adequate intake level, where a recommended dietary allowance cannot be based on an estimated average requirement.

Tolerable upper intake levels above which risk of toxicity would increase. Along with dietary reference values for the intakes of nutrients by Americans and Canadians, this book presents recommendations for health maintenance and the reduction of chronic disease risk. Also included is a Summary Table of Dietary Reference Intakes, an updated practical summary of the recommendations. In addition, Dietary Reference Intakes: The Essential Reference for Dietary Planning and Assessment provides information about:

Guiding principles for nutrition labeling and fortification

Applications in dietary planning

Proposed definition of dietary fiber

A risk assessment model for establishing upper intake levels for nutrients

Proposed definition and plan for review of dietary antioxidants and related compounds

A free PDF download of an errata page to Dietary Reference Intakes: The Essential Guide to Nutrient Requirements is available from: http://books.nap.edu/html/11537/dri_errata.pdf.

Food can be mislabeled anywhere along a long supply chain. In the case of sushi, the labeling could happen on the fishing boat, at the docks, in the warehouse, in the retail store or the restaurant. It pays to be skeptical and check things out occasionally. Of course, it could be helpful to have a macrobiologist along with you :-), but we can all ask questions, read labels, and prepare food at home with locally grown ingredients whenever possible.

I don't normally cover cures for specific problems, but this one is personal!  Having had H. Pylori and been treated...and feeling the results of the treatment, I began to research how common it is ... and whether there are known causes.   With mixed results, I might add.

But this article about treatment research caught my eye.  If you have gastric indigestion, sensitivities to certain foods (for me it was sugar), belching, etc, etc. etc.  you might want to ask your doctor about this very common bacterial infection.

New Combination Therapy Looks Promising Against Ulcer Bacteria

Trial in Untreated Patients Suggests 7-Day Regimen as Good as 10-Day Treatment

Newswise -- Helicobater pylori, a bacteria implicated in peptic ulcers and gastritis, was eradicated in 95 percent patients who took a 7-day course of combination therapy with levofloxacin, omeprazole, nitazoxanide (Alinia®) and doxycycline (LOAD) compared to eradication in only 80.9 percent of patients on lansoprazole, amoxicillin and clarithromycin (LAC) for seven days.

Results of a new study presented at the Annual Scientific Meeting of the American College of Gastroenterology reveal LOAD therapy is superior to LAC at eliminating the bacterium in patients with gastritis and peptic ulcers. Moreover, Dr. Patrick Basu and his colleagues at Columbia University College of Physicians and Surgeons found that a shorter course of the four-drug combination, seven days vs. a ten-day treatment, is equally effective.

The study included 135 patients with treatment naïve Helicobacter pylori infection who were randomized to LOAD (7 or 10 days) vs. LAC (10 days). There was a total wash out period of six weeks from any prior antibiotic and PPI use prior to the initiation of therapy.

"H. pylori gastritis is a global threat for gastric carcinoma and many therapies have been explored to eradicate this infection with variable success rates," explained Dr. Basu.

"Our study demonstrates the therapeutic superiority of LOAD therapy over LAC therapy in a treatment naïve population of patients with H. pylori."

About the American College of Gastroenterology

Founded in 1932, the American College of Gastroenterology (ACG) is an organization with an international membership of more than 11,000 individuals from 80 countries. The College is committed to serving the clinically oriented digestive disease specialist through its emphasis on scholarly practice, teaching and research. The mission of the College is to serve the evolving needs of physicians in the delivery of high quality, scientifically sound, humanistic, ethical, and cost-effective health care to gastroenterology patients. www.acg.gi.org

Source: American College of Gastroenterology (ACG)